Asian Journal of Research and Reports in Endocrinology <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Endocrinology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRRE/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Endocrinology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> Asian Journal of Research and Reports in Endocrinology en-US Asian Journal of Research and Reports in Endocrinology Role of Social Media Usage in Promoting Positive Knowledge, Attitudes, and Behaviours to Combat Diabetes Mellitus in Saudi Population <p><strong>Background:</strong> The aim of this study is to determine the level of use of social media (SoMe) for diabetic health promotion, prevention, and positive lifestyle changes to combat diabetes mellitus (DM) and to determine its main source of knowledge.</p> <p><strong>Methods:</strong> A cross-sectional survey was conducted in Jeddah City/Saudi Arabia among 405 consented adults of both sexes. A self-administered questionnaire was used to collect data on social media use and the preferable sources of health-related information as well as to test their level of knowledge on DM.</p> <p><strong>Results:</strong> The mean age of the overall participants was 32.8 years; 55.8% were males, and 98% were social media users with high use of WhatsApp apps. The overall level of knowledge on the nature of DM was 52.1%. Post-adjustment regression of the demographic covariant, females was the more likely user of social media in promoting positive knowledge and prevention to combat diabetes mellitus than males (AOR: 1.917; 95% CI: 1.151-3.192), older age versus younger (AOR 3.517; 95% CI:1.268-9.757), and married participants (AOR 1.925; 95% CI: 1.091-3.394).</p> <p><strong>Conclusion:</strong> The growing trend in the use of social media should be strongly considered as an avenue for improving knowledge, skills, and empowering self-engagement in the promotion of such chronic diseases like DM and will provide a fruitful avenue for future research. Our results showed positive implications of social media use via enhancement of the official MOH platform or other health institutions in the country.</p> Alaa Alhaeli Amen Bawazir ##submission.copyrightStatement## 2020-07-21 2020-07-21 6 22 Foot Vibration to Improve Foot Sensitivity and Ankle Brachial Index and Relief Pain Sensation in Type 2 Diabetes Mellitus Patients <p>Exercise is one way to achieve good glycemic control and complication prevention. These study analysed effect of foot vibration to pain, foot sensitivity and ankle brachial index (ABI) improvement on type 2 diabetes mellitus (DM) patients. These study used pre-experiment one group pre and post test design with 20 samples, collected by using consecutive sampling. Intervention was provide foot vibration for 8 weeks at public health center of Abiansemal II Badung, Bali. The result showed mean of foot pain (right: 4.35. left: 3.85), foot sensitivity (right: 2.85, left: 3.05) and ABI (right: 0.82, left: 0.85) before intervention. Neuropathy and ABI improved after intervention with mean of foot pain (right: 3.35. left: 2.70, p=0.001), foot sensitivity (right: 1.50, left: 1.35, p=0.001) and ABI (right: 0.82, left: 0.85, p=0.001). For the result concluded that foot vibration was effective to improve neuropathy n ABI on type 2 DM patients.</p> I. Dewa Putu Gede Putra Yasa V. M. Endang S. P. Rahayu I. Made Widastra Gusti Ayu Ari Rasdini I. Ketut Labir I. Wayan Surasta ##submission.copyrightStatement## 2020-08-05 2020-08-05 23 28 Toxicological Assessment of a Polyherbal Mixture on Organ Weights and Hormonal Profile in Exposed Wistar Rats <p>Hormonal imbalance and hypertrophy of internal organs are sensitive indices of toxicity which may be multifactorial (including exposure to certain foods, drugs and herbal remedies), and are implicated in certain conditions such as infertility amongst others. Dr Iguedo Goko Cleanser® is a polyherbal mixture (PHM) often described by promoters as ‘super effective’ for the treatment of various ailments. The present study was aimed to evaluate the exposure-related effects of PHM on hormonal profile and weight of internal organs in Wistar rats of both gender. Thirty Wistar rats (both genders) randomly allotted to six groups (5 in each group) were exposed orally to PHM for 60 days. Control groups (1 and 4; 10 mL/kg distilled water), groups 2-3 and 5-6 received PHM (476.24; 158.75 mg/kg) respectively. On 62nd day, animals were euthanized under diethyl ether anaesthesia and sacrificed. Blood samples were collected for hormonal analysis and vital organs were eviscerated for macroscopic examinations. PHM significantly (<em>P</em>=.05) decreased spleen weight in female subjects relative to control. However, female rats had higher spleen weights compared to male rats. HDF (high dose females) had increased brain weight relative to control groups. Female rats had dose-dependent increased in progesterone relative to control. Female rats had higher progesterone concentration relative to males. Female rats recorded increased estradiol compared to male rats. However, this was reduced in HDF relative to control; low dose females had elevated estradiol compared to control and HDF. Results of the present day study strongly suggest caution and good judgement as regards the prolonged use of the polyherbal mixture especially as the probable hypertrophy of the brain observed in experimental female rats is not negligible.</p> Godswill J. Udom John A. Udobang Daniel N. Obot Nkechi J. Onyeukwu Ikanna E. Asuquo Jude E. Okokon ##submission.copyrightStatement## 2020-08-13 2020-08-13 29 36 An in vivo Evaluation of Antidiabetic and Depressant Action of Bark of Swietenia mahagoni on Alloxan-Induced Diabetic Rat Model <p>Diabetes is a type of medical disorder originated from abnormal metabolic condition and derivatives of natural products are used as a tool to fight against this pernicious disease. Plant is a diversified origin of various chemical compounds of medicinal significance which can be applied to mitigate diabetic disorder.&nbsp; Leafs of <em>Swietenia mahagoni</em> are used for this reason conventionally as a tradition for long period of time. Our purposes were to find out the anti-diabetic effect of <em>Swietenia mahagoni</em> by investigating its extract obtained from its leaves and also establishing its safety profile so that it can be applied to alleviate diabetic disorder. Induction of diabetes in rats were done by applying intraperitoneal injection containing alloxen. Dose of alloxen given were 150 mg/kg bodyweight. Rats were fed the extract of <em>Swietenia mahagoni</em> leaves by maintaining the dose at 750 mg/kg. Blood glucose level and safety profile were measured by evaluating SGOT,SGPT and creatinine level on both non-diabetic and diabetes induced rats prior and after the extract administration. It was noticed that the anti-diabetic effect was similar to that of metformin (p˃ 0.05) administrated at the dose of 500mg/kg. Investigation of&nbsp; SGPT,SGOT and creatinine level were done to evaluate safety profile. It was observed that the induced diabetic conditions were improved for both metformin and leaf extract. And there were no significant change observed in the rats with nomal physiological condition. Again the extract showed significant depressant effect in tail suspension test and sucrose preference test. It may be therefore surmised that the leaf extract of <em>Swietenia mahagoni</em> could become a potential therapeutic alternative against diabetes mellitus and depressant.</p> Lia Rose Merry D. Cruze Amena Alam Shanta Md. Saqline Mostaq Amira Mostafa Md. Kamrul Hasan Farhan Rashid Sadia Afrin Jumana Ahsan Sanzida Khondoker Md. Billal Hossain ##submission.copyrightStatement## 2020-09-05 2020-09-05 37 45 What are the Barriers to Patient Engagement in Managing Type 2 Diabetes? How Can We Overcome Them?: A Review Article <p>Diabetes Mellitus (DM) is a chronic disorder resulting from the deficiency of insulin in the body, disturbance of insulin action or both, resulting in high blood glucose levels causing long term complications.&nbsp;</p> <p>Diabetes is well known to increase cardiovascular risk because of its association with obesity, sedentary life style, hypertension, hyper or dyslipidemia and a tendency to develop thrombosis. Diabetic patients can have poor quality of life and reduced life expectancy due to its long term macro-vascular and micro-vascular complications.&nbsp; The aim of this article is to highlight the many barriers to patients’ engagement in their management of diabetes and the ways how they can be overcomed.</p> <p>The author during day to day practice came across many barriers while managing diabetic patients. Extensive searches were done on electronic databases like MEDLINE/PubMed and google scholar, with medical headings diabetes, type 2 diabetes and barriers to management.<em>Diabetes mellitus</em></p> Muhammad Iqbal ##submission.copyrightStatement## 2020-07-11 2020-07-11 1 5