Evaluation of Fertility Hormones in Type 2 Diabetic Male Subjects in Nauth, Nnewi

Chiazoka Frances Nduka *

Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.

Ignatius C Maduka

Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.

Patrick Onochie Manafa

Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.

Collins Uchechukwu Obi

Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.

Chinenye Stellamaris Okeke

Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.

Anthonia Chinenye Ogueze

Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Background and Aim of Study: To Assess the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone among type 2 diabetic male subjects in NAUTH, NNEWI.

Methodology: This was a cross sectional study carried out at Endocrinology unit, NAUTH Nnewi. A total of 134  participants were recruited for this study which comprised of 67  male type 2 diabetics  mellitus subjects and 67 apparently healthy controls. The levels of testosterone, LH, FSH and glycated hemoglobin were analysed using ELISA and colorimetric assay methods respectively.

Results: Results from this findings showed that the mean levels of glycated hemoglobin (HbA1c), LH and FSH were significantly higher in test subjects compared with that of the control subjects (p<0.05). Conversely, the mean level of testosterone was significantly lower in the type 2 diabetic male subjects compared to that of the control subjects (p<0.05) In male type 2 diabetic participants, there was a significant positive correlation between the mean levels of HbA1c and the mean levels of LH (r=0.385, p=0.001) and FSH (r=0.535, p<0.001). Nevertheless, among the male type 2 diabetic participants, there was no significant correlation (p>0.05) between the mean HbA1c levels and testosterone. In the control group, there was a significant positive correlation (r=0.461, p<0.001) between the mean values of HbA1c and FSH.

Conclusion: This suggests there is hypogonadism which is indicative of an alteration in the hypothalamic-pitutary -gonadal axis and this could lead to infertility in type 2 diabetic male subjects.

Keywords: Diabetes mellitus, glycated hemoglobin/HbA1c, FSH, LH, testosterone


How to Cite

Nduka, Chiazoka Frances, Ignatius C Maduka, Patrick Onochie Manafa, Collins Uchechukwu Obi, Chinenye Stellamaris Okeke, and Anthonia Chinenye Ogueze. 2024. “Evaluation of Fertility Hormones in Type 2 Diabetic Male Subjects in Nauth, Nnewi”. Asian Journal of Research and Reports in Endocrinology 7 (1):78-86. https://journalajrre.com/index.php/AJRRE/article/view/96.

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