Evaluation of Fertility Hormones in Type 2 Diabetic Male Subjects in Nauth, Nnewi
Published: 2024-07-23
Page: 78-86
Issue: 2024 - Volume 7 [Issue 1]
Chiazoka Frances Nduka *
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Ignatius C Maduka
Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Patrick Onochie Manafa
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Collins Uchechukwu Obi
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Chinenye Stellamaris Okeke
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Anthonia Chinenye Ogueze
Department of Chemical Pathology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background and Aim of Study: To Assess the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone among type 2 diabetic male subjects in NAUTH, NNEWI.
Methodology: This was a cross sectional study carried out at Endocrinology unit, NAUTH Nnewi. A total of 134 participants were recruited for this study which comprised of 67 male type 2 diabetics mellitus subjects and 67 apparently healthy controls. The levels of testosterone, LH, FSH and glycated hemoglobin were analysed using ELISA and colorimetric assay methods respectively.
Results: Results from this findings showed that the mean levels of glycated hemoglobin (HbA1c), LH and FSH were significantly higher in test subjects compared with that of the control subjects (p<0.05). Conversely, the mean level of testosterone was significantly lower in the type 2 diabetic male subjects compared to that of the control subjects (p<0.05) In male type 2 diabetic participants, there was a significant positive correlation between the mean levels of HbA1c and the mean levels of LH (r=0.385, p=0.001) and FSH (r=0.535, p<0.001). Nevertheless, among the male type 2 diabetic participants, there was no significant correlation (p>0.05) between the mean HbA1c levels and testosterone. In the control group, there was a significant positive correlation (r=0.461, p<0.001) between the mean values of HbA1c and FSH.
Conclusion: This suggests there is hypogonadism which is indicative of an alteration in the hypothalamic-pitutary -gonadal axis and this could lead to infertility in type 2 diabetic male subjects.
Keywords: Diabetes mellitus, glycated hemoglobin/HbA1c, FSH, LH, testosterone