Pancreatic Lipid Deposits: Is there a Connection to Pre-diabetes and Diabetes Mellitus?

Dilara Bulut Gökten *

Department of Rheumatology, Namık Kemal University, Tekirdağ, Türkiye.

Gülsüm Kübra Bahadir

Department of Radiology, Ankara City Hospital, Ankara, Türkiye.

Amed Trak

Department of Internal Medicine, Ankara City Hospital, Ankara, Türkiye.

Lale Damgaci

Department of Radiology, Ankara City Hospital, Ankara, Türkiye.

Ihsan Ateş

Department of Internal Medicine, Ankara City Hospital, Ankara, Türkiye.

*Author to whom correspondence should be addressed.


Abstract

Objective: The study focused on elucidating the presence of pancreatic steatosis in pre-diabetes and diabetes mellitus along with investigating the correlation between pancreatic steatosis and metabolic parameters.

Methods: This research involved 314 patients who sought treatment at internal medicine outpatient and inpatient clinics from April 2022 to May 2023. Patients who underwent non-enhanced abdominal computed tomography for any reason were included in the study. The patients were categorized into three groups: healthy controls(n=103), diabetes individuals(n=109), and prediabetes individuals(n=102).

Results: The study aimed to explore the relationship between pancreatic steatosis and metabolic parameters. The findings revealed that HDL level, albumin, and glomerular filtration rate (GFR) showed a positive correlation with pancreatic density, indicating a lower degree of steatosis in the pancreatic tissue. Conversely, patients with higher levels of HbA1c, uric acid, blood glucose levels, body mass index, INR exhibited a higher degree of pancreatic steatosis.

Furthermore, the research identified the presence of pancreatic steatosis in prediabetes patients. There was no significant difference in pancreatic steatosis between prediabetes and diabetes patients, suggesting that their pancreatic densities were statistically similar(p=0,08).

Conclusion: Our study investigated pancreatic steatosis in diabetes and pre-diabetes patients, and its relationship with metabolic parameters.The findings suggest that pancreatic steatosis is also present in the prediabetes phase and it has a correlation with metabolic parameters seen in diabetes process.

Keywords: Diabetes mellitus, prediabetic state, steatosis, hemoglobin A1c protein


How to Cite

Gökten, Dilara Bulut, Gülsüm Kübra Bahadir, Amed Trak, Lale Damgaci, and Ihsan Ateş. 2024. “Pancreatic Lipid Deposits: Is There a Connection to Pre-Diabetes and Diabetes Mellitus?”. Asian Journal of Research and Reports in Endocrinology 7 (1):40-46. https://journalajrre.com/index.php/AJRRE/article/view/90.

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References

Prasad MK, Mohandas S, Ramkumar KM. Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes. Apoptosis. 2023;28(7-8):958-76.

Mahdipour E, Azizian M, Mirhafez SR, Ganjali S, Shoeibi S, Nematy M, et al. Relationship between serum pro-and anti-inflammatory cytokine and growth factor concentrations with the age and gender adjusted prevalence of diabetes and pre-diabetes. International Journal of Diabetes in Developing Countries. 2017;37:313-9.

Olsen TS. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol Microbiol Scand A. 1978;86a(5):367-73.

Zhou J, Li ML, Zhang DD, Lin HY, Dai XH, Sun XL, et al. The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population. Pancreatology. 2016;16(4):578-83.

Berger Z, Orellana F, Cocio R, Torres F, Simian D, Araneda G, Toledo P. Pancreatic steatosis: A frequent finding in a Chilean population. Rev Gastroenterol Mex (Engl Ed). 2023;88(2):118-24.

Gerst F, Wagner R, Oquendo MB, Siegel-Axel D, Fritsche A, Heni M, et al. What role do fat cells play in pancreatic tissue? Mol Metab. 2019;25:1-10.

Lee JS, Kim SH, Jun DW, Han JH, Jang EC, Park JY, et al. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol. 2009;15(15):1869-75.

van der Zijl NJ, Goossens GH, Moors CC, van Raalte DH, Muskiet MH, Pouwels PJ, et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab. 2011;96(2):459-67.

Jia DM, Fukumitsu KI, Tabaru A, Akiyama T, Otsuki M. Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. Am J Physiol Regul Integr Comp Physiol. 2001;280(5):R1332-40.

Sezgin O, Yaraş S, Özdoğan O. Pancreatic Steatosis Is Associated with Both Metabolic Syndrome and Pancreatic Stiffness Detected by Ultrasound Elastography. Dig Dis Sci. 2022;67(1):293-304.

Sunouchi M, Inaishi J, Shimizu-Hirota R, Saisho Y, Hayashi K, Takaishi H, Itoh H. Longitudinal changes in pancreatic volume and pancreatic fat with weight gain in Japanese without diabetes: An analysis using health check-up data. Metabol Open. 2023;19:100250.

Salman AA, Salman MA, Said M, El Sherbiny M, Elkassar H, Hassan MB, et al. Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery. Front Med (Lausanne). 2022;9:894465.

Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression. Metabolism. 2017;69:1-13.

Volk BW, Wellmann KF. Quantitative studies of the islets of nondiabetic patients. The diabetic pancreas: Springer; 1985. p. 117-25.

Uygun A, Kadayifci A, Demirci H, Saglam M, Sakin YS, Ozturk K, et al. The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis. Eur J Intern Med. 2015; 26(1):37-41.

Criddle DN. The role of fat and alcohol in acute pancreatitis: A dangerous liaison. Pancreatology. 2015;15(4 Suppl): S6-s12.

Zhou M, Zhu L, Cui X, Feng L, Zhao X, He S, et al. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status. Lipids Health Dis. 2016;15:104.

Drew BG, Duffy SJ, Formosa MF, Natoli AK, Henstridge DC, Penfold SA, et al. High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation. 2009;119(15):2103-11.

von Eckardstein A, Widmann C. High-density lipoprotein, beta cells, and diabetes Cardiovasc Res. 2014;103(3): 384-94.

Wan X, Xu C, Lin Y, Lu C, Li D, Sang J, et al. Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. J Hepatol. 2016;64(4):925-32.

King C, Lanaspa MA, Jensen T, Tolan DR, Sánchez-Lozada LG, Johnson RJ. Uric Acid as a Cause of the Metabolic Syndrome. Contrib Nephrol. 2018;192:88-102.