Asian Journal of Research and Reports in Endocrinology

The aim of this study was to evaluate the biochemical changes in diabetic Wistar rats administered methanol leaf extract of Andropogon gayanus. Freshly harvested leaves of A. gayanus were processed into extract. Twenty-five adult male Wistar rats were divided into five groups of five rats per group. Group I was the normal control and was administered 2 mL of distilled water. Group II: was induced diabetes without treatment. Group III: were diabetic rats treated with 100 mg/kg of A. gayanus leaf extract. Group IV: was diabetic rats treated with 200 mg/kg of A. gayanus leaf extract. Group V: was diabetic rats treated with standard drugs. The activities of AST, ALT and ALP in diabetic groups treated with the aforementioned extract were significantly (P<0.05) lower than those reported for the normal control. However, a contrary observation was made on the serum albumin and total protein. Total cholesterol (TC) and Triglycerides as well as Low-Density Lipoprotein reported for groups treated with extract were significantly (P<0.05) higher than those reported for the negative control. However, a contrary observation was made on the High-Density Lipoprotein (HDL). Serum creatinine and urea reported for the negative control were significantly (P<0.05) higher than those reported groups administered leaf extract of Andropogon gayanus. In conclusion, it can be deduced from this study that methanol leaf extract of Andropogon gayanus has influence on the indices evaluated which can be traced to the biological activities of certain active ingredients inherent in them.