Asian Journal of Research and Reports in Endocrinology

Evaluation of Serum Calcitonin, Creatinine and Uric Acid on CKD Patients at Various Stages with Thyroid Abnormality Complication

Christian Ugege *

Edo Specialist Teaching Hospital, Benin City, Edo State, Nigeria and Department of Medical Laboratory Science, Faculty of Health Science, Edo State University, Uzairue, Edo State, Nigeria.

Edebiri, O. E.

Department of Physiology, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

Ohiwerei W. O.

Department of Medical Laboratory Science, Faculty of Health Science, Edo State University, Uzairue, Edo State, Nigeria and Department of Research and Training, Ohilux Global Research Diagnostic and Training Centre, Ekpoma, Edo State, Nigeria.

Malachi, E. E.

Romford, 3 Staple Close, United Kingdom.

Lauretta A. O.

Paxxmed Diagnostic Service, Abuja, Nigeria.

Ogedegbe I. S.

Narrow Way Clinic Aduwawa, Benin City, Edo State, Nigeria.

Otaye, O. M.

Department of Research and Training, Ohilux Global Research Diagnostic and Training Centre, Ekpoma, Edo State, Nigeria and Romford, 3 Staple Close, United Kingdom.

Glory Ugege

Ambrose Alli University, Ekpoma, Edo State, Nigeria.

Vincent Ugege

Ambrose Alli University, Ekpoma, Edo State, Nigeria.

*Author to whom correspondence should be addressed.

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Abstract

CKD (Chronic Kidney Disease) is a progressive condition that affects the kidneys' ability to filter blood and remove waste products from the body. Calcitonin is a hormone produced by the thyroid gland that regulates calcium levels in the body.  The aim of this study was to evaluate the serum calcitonin, creatinine and uric acid on CKD patients at various stages with thyroid abnormality complication. the study population for this research are renal unit patients attending clinic at the Irrua Specialist Teaching Hospital, Benin City, Edo state, Nigeria. This study was carried out at the Irrua specialist Teaching Hospital, Edo State.  Total Thyroxine (T₄), total triiodothyronine (T₃), total triiodothyronine (T₃) and Calcitonin Estimation were estimated using ELISA Method, Uric acid and Creatinine by Jaffe Reaction were estimated calorimetrically. Data was collected, screened for completeness and entered into the SPSS version 20 for analysis. The result shows the serum levels of Calcitonin, T3, T4, TSH, creatinine, uric Acid based on different stages of renal disease patients, calcitonin Stage 3 (85.7±17.3) Stage 4 (109±16.8) Stage 5 (74.5±17.8). T3 Stage 3 (0.773±0.0771) Stage 4 (0.731±0.0419)  Stage 5 (0.48±0.0288). T4 Stage 3 (12.9±5.45) Stage 4 (8.06±0.255) Stage 5 (5.35±0.2). TSH Stage 3 (5.63±0.620) Stage 4 (15.2±4.72) Stage 5 (6.91±0.644). Creatinine Stage 3 (7.04±0.823) Stage 4 (8.33±0.797) Stage 5 (9.11±1.41). Uric Acid Stage 3 (15.6±1.74) Stage 4 (14.1±0.993) Stage 5 (15.7±2.35). There was no relationship between the serum levels of Calcitonin, T3, T4, TSH, creatinine, and uric acid based on different stages of renal disease is that these markers are influenced by different physiological processes, and the changes in these processes that occur in CKD can vary among individuals. In conclusion, there was no relationship between the serum levels of Calcitonin, T3, T4, TSH, creatinine, and uric acid based on different stages of renal disease is that these markers are influenced by different physiological processes, and the changes in these processes that occur in CKD can vary among individuals.

Keywords: Calcitonin, chronic kidney disease, uric acid, thyroid abnormality

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