Asian Journal of Research and Reports in Endocrinology

A Review on Comprehensive Consequences of Gall Stones as Concomitant Disease in Hypothyroidism (CCCCH)

Sana Tabassum

St. Pauls College of Pharmacy, Affiliated to Osmania University, Turkayamjal, Hyderabad, Telangana, 501510, India.

Soujanya Durishetty

St. Pauls College of Pharmacy, Affiliated to Osmania University, Turkayamjal, Hyderabad, Telangana, 501510, India.

Mohammed Sabeeh Uddin

St. Pauls College of Pharmacy, Affiliated to Osmania University, Turkayamjal, Hyderabad, Telangana, 501510, India.

Thumukunta Komal

St. Pauls College of Pharmacy, Affiliated to Osmania University, Turkayamjal, Hyderabad, Telangana, 501510, India.

Are Anusha *

Department of Pharmacy Practice, St. Pauls College of Pharmacy, Affiliated to Osmania University, Turkayamjal, Hyderabad, Telangana, 501510, India.

*Author to whom correspondence should be addressed.

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Abstract

This review investigates the potential correlation between hypothyroidism and gallstone disease, with a particular focus on subclinical hypothyroidism. The study explores the physiological factors that may contribute to gallstone formation in hypothyroid patients, including changes in bile flow and sphincter of Oddi dysfunction. The review also highlights the role of thyroid hormones in lipid metabolism and their potential impact on the composition of bile. The findings suggest a significant association between gallstone disorders and thyroid malfunction, particularly subclinical hypothyroidism. The review concludes that early identification and treatment of subclinical hypothyroidism could significantly reduce biliary stone disease in patients. regular monitoring of thyroid levels in hypothyroid individuals is recommended to prevent complications due to abnormal thyroid hormone levels.

Keywords: Hypothyroidism, gallstone disease, subclinical hypothyroidism, thyroid hormone level, biliary stone disease

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References

Ramezani Tehrani F, Aghaee M, Asefzadeh S. The comparison of thyroid function tests in cord blood following cesarean section or vaginal delivery. Int J Endocrinol Metab. 2003;1:22–26.

Zadeh-Vakili A, Ramezani Tehrani F, Hashemi S, Amouzegar A, Azizi F. Relationship between sex hormone binding globulin, thyroid stimulating hormone, prolactin and serum androgens with metabolic syndrome parameters in Iranian women of reproductive age. Diabetes Metabolism. 2012:S:2.

Beckingham IJ, Rowlands BJ. Post cholecystectomy problems, Blumgart H. (Ed.). Surgery of liver and biliary tract (third ed.), WB Saunders, London. 2000;186. PMCID: PMC1119388.

Nakeeb A, Comuzzie AG, Martin L, et al. Gallstones: Genetics versus environment Ann. Surg. 2002;235:842.

Al-Jiffry B, Shaffer E, Saccone G. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol. 2003;17:169.

Henry Völzke, Daniel M Robinson, Ulrich John. Association between thyroid function and gallstone disease; World Journal of Gastroenterology. 2005;11(35);5530-5534.

Yawar Zahoor Watali, Rahul Jain, Rajandeep Singh Bali, Ankul Mittal; Is hypothyroidism a risk for gallstone disease? A study to assess the association; International Surgery Journal. 4(8): 2665-2669.

Rana Ranjit, Arun Gupta, Sukrit Shah, Avreen Singh, Amrit Pal, Singh Bhatia. Prevalence of hypothyroidism in patients with biliary stone: A prospective study Int surg J. 2016;3:2022-2024.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160:526–534.

Laukkarinen J, Sand J, Saaristo R, Salmi J, Turjanmaa V, Vehkalahti P, Nordback I. Is bile flow reduced in patients with hypothyroidism? Surgery. 2003;133:288–293.

Hassan H. Zaini, Kussay M. Zwain; Prevalence of hypothyroidism in patients with gallstone disease; AL-Qadisiyah Medical Journal. 2010;6(10);108-117.

Inkinen J, Sand J, Arvola P, Pörsti I, Nordback I. Direct effect of thyroxine on pig sphincter of Oddi contractility. Dig Dis Sci. 2001;46:182–186.

Cicala M, Habib FI, Fiocca F, Pallotta N, Corazziari E. Increased sphincter of Oddi basal pressure in patients affected by gallstone disease: A role for biliary stasis and colickypain? Gut. 2001;48:414–417.

Suaad L. Ibrahim the impact of thyroid dysfunction and tsh on the pathogenesis of gallstone and its composition. Journal of Kufa for Nursing Science. 2014;4;1.

Inkinen J, Sand J, Nordback I: Association between common bile duct stones and treated hypothyroidism. Hepatogastro-enterology. 2000;47:919-21.

Kharishma P. Nair, Siddharth Gowthaman. Thyroid function and gallstone disease; is there an association? International Surgery Journal Int Surg j. 2021;89(5):1670-1673.

Mir Mujtaba Ahmad, Mir Irfan Nazir, Haneef Mohamed Dar, Ubaid Ali, Moonis Mirza, Khalid Kawoosa, Evaluation of thyroid profile in biliary tract stones. International Surgery Journal Ahmad MM et al. Int Surg J. 2015;2(3):344-347.

Johanna Laukkarinen, Juhani Sand, Isto Nordback. The underlying mechanisms: How hypothyroidism affects the formation of common bile duct stones—A review Hindawi Publishing Corporation HPB Surgery. 2012;2012:7.

Sun H, Tang H, Jiang S, Zeng L, Chen EQ, Zhou TY. Gender and metabolic differences of gallstone diseases. World J Gastroenterol WJG. 2009;15(15):1886–91.

Johanna Laukkarinen, Gediminas Kiudelis, Marko Lempinen, Sari Ratu, Hanna Pelli, Juhani Sand, Esko Kemppainen, Caj Haglund, Isto Nordback. Increased prevalence of subclinical hypothyroidism in common bile duct stone patients. The Journal of Clinical Endocrinology & Metabolism. 2007;92(11):4260–4264.

Bj SC, Kb N, Goutham M. Hypothyroidism as a risk factor for choledocholithiasis: A case-control study in an Indian population. Int J Surg Sci.2019;3(4):439-44.

Pradeep Ghimire MS, Frcs ED. Association of gallstone disease with hypothyroidism in Western Region of Nepal. IOSR J Dental and Med Sci. 2017; 16(8):40-2.

Völzke H, Robinson DM, John U. Association between thyroid function and gallstone disease. World J Gastroenterol WJG. 2005;11(35):5530–4.

Milionis A, Milionis C. Correlation between body mass index and thyroid function in euthyroid individuals in Greece. ISRN Biomarkers. Hindawi; 2013;2013: pe651494.