An in vivo Evaluation of Antidiabetic and Depressant Action of Bark of Swietenia mahagoni on Alloxan-Induced Diabetic Rat Model

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Lia Rose Merry D. Cruze
Amena Alam Shanta
Md. Saqline Mostaq
Amira Mostafa
Md. Kamrul Hasan
Farhan Rashid
Sadia Afrin
Jumana Ahsan
Sanzida Khondoker
Md. Billal Hossain

Abstract

Diabetes is a type of medical disorder originated from abnormal metabolic condition and derivatives of natural products are used as a tool to fight against this pernicious disease. Plant is a diversified origin of various chemical compounds of medicinal significance which can be applied to mitigate diabetic disorder.  Leafs of Swietenia mahagoni are used for this reason conventionally as a tradition for long period of time. Our purposes were to find out the anti-diabetic effect of Swietenia mahagoni by investigating its extract obtained from its leaves and also establishing its safety profile so that it can be applied to alleviate diabetic disorder. Induction of diabetes in rats were done by applying intraperitoneal injection containing alloxen. Dose of alloxen given were 150 mg/kg bodyweight. Rats were fed the extract of Swietenia mahagoni leaves by maintaining the dose at 750 mg/kg. Blood glucose level and safety profile were measured by evaluating SGOT,SGPT and creatinine level on both non-diabetic and diabetes induced rats prior and after the extract administration. It was noticed that the anti-diabetic effect was similar to that of metformin (p˃ 0.05) administrated at the dose of 500mg/kg. Investigation of  SGPT,SGOT and creatinine level were done to evaluate safety profile. It was observed that the induced diabetic conditions were improved for both metformin and leaf extract. And there were no significant change observed in the rats with nomal physiological condition. Again the extract showed significant depressant effect in tail suspension test and sucrose preference test. It may be therefore surmised that the leaf extract of Swietenia mahagoni could become a potential therapeutic alternative against diabetes mellitus and depressant.

Keywords:
Swietenia mahagoni, alloxan, diabetes mellitus, rat, SGOT, SGPT, creatinine, depressant, tail suspension test

Article Details

How to Cite
Cruze, L. R. M. D., Shanta, A. A., Mostaq, M. S., Mostafa, A., Hasan, M. K., Rashid, F., Afrin, S., Ahsan, J., Khondoker, S., & Hossain, M. B. (2020). An in vivo Evaluation of Antidiabetic and Depressant Action of Bark of Swietenia mahagoni on Alloxan-Induced Diabetic Rat Model. Asian Journal of Research and Reports in Endocrinology, 3(2), 37-45. Retrieved from https://journalajrre.com/index.php/AJRRE/article/view/30114
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Original Research Article

References

Daisy P, Jasmine R, Ignacimuthu S, Murugan E. A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity. Phytomedicine. 2009;16(2-3):252–257. View at Publisher• View at Google Scholar.• View at Scopus

World Health Organization, World Health Organization Expert Committee on Diabetes Mellitus: Second Report, Technical Report Series, no. 646, WHO, Geneva, Switzerland; 1980.

Badole SL, Patel NM, Thakurdesai PA, Bodhankar SL. Interaction of aqueous extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in alloxan induced diabetic mice. Evidence-Based Complementary and Alternative Medicine. 2008;5(2):159–164. View at Publisher• View at Google Scholar• View at Scopus.

Hsu JH, Wu YC, Liou SS, Liu IM. Mediation of endogenous β-endorphin by tetrandrine to lower plasma glucose in streptozotocin-induced diabetic rats. Evidence-Based Complementary and Alternative Medicine. 2004;1:193–201. View at Google Scholar.

Innes KE, Vincent HK. The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: A systematic review. Evidence-Based Complementary and Alternative Medicine. 2007;4(4):469–486. View at Publisher• View at Google Scholar• View at Scopus.

Maiti R, Das UK, Ghosh D. Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biological and Pharmaceutical Bulletin. 2005;28(7):1172–1176. View at Publisher• View at Google Schola • View at Scopus.

Mallick C, Maiti R, Ghosh D. Comparative study on antihyperglycemic and antihyperlipidemic effects of separate and composite extract of seed of Eugenia jambolana and root of Musa paradisiaca in streptozotocin-induced diabetic male albino rat. Iranian Journal of Pharmacology and Therapeutics. 2006;5(1):27–33. View at Google Scholar• View at Scopus.

Mallick C, Maiti R, Ghosh D. Antidiabetogenic effects of separate and composite extract of seed of Jamun (Eugenia jambolana) and root of Kadali (Musa paradisiaca) in streptozotocin-induced diabetic male albino rat: a comparative study. International Journal of Pharmacology. 2006;2(5):492–503. View at Publisher• View at Google Scholar• View at Scopus.

Ljubuncic P, Azaizeh H, Cogan U, Bomzon A. The effects of a decoction prepared from the leaves and unripe fruits of Crataegus aronia in streptozotocin-induced diabetic rats. Journal of Complementary and Integrative Medicine. 2006;3(1):6. View at Google Scholar• View at Scopus.

Sharma A, Vijayakumar M, Rao CV, Unnikrishnan MK, Reddy GD. Action of Portulaca oleracea against streptozotocin-induced oxidative stress in experimental diabetic rats. Journal of Complementary and Integrative Medicine. 2009;6(1):1. View at Publisher• View at Google Scholar• View at Scopus.

Bhat M, Kothiwale SK, Tirmale AR, Bhargava SY, Joshi BN. Antidiabetic properties of Azardiracta indica and Bougainvillea spectabilis: In vivo studies in murine diabetes model. Evidence-Based Complementary and Alternative Medicine. 2009;6:1–8. View at Google Scholar.

Said O, Fulder S, Khalil K, Azaizeh H, Kassis E, Saad B. Maintaining a physiological blood glucose level with ‘glucolevel’, a combination of four anti-diabetes plants used in the traditional Arab herbal medicine. Evidence-Based Complementary and Alternative Medicine. 20085(4):421–428. View at Publisher• View at Google Scholar• View at Scopus.

Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Gosha-jinki-gan (a Herbal Complex) corrects abnormal insulin signaling. Evidence-Based Complementary and Alternative Medicine. 2004;1:269–276. View at Google Scholar.

Rao BK, Sudarshan PR, Rajasekhar MD, Nagaraju N, Rao CA. Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats. Journal of Ethno-pharmacology. 2003;85(1):169–172.

Sathish R, Natarajan K, Selvakumar S. Antidiabetic activity of Swietenia mahagoni seed powder in alloxan induced diabetic mice. Research J. Pharmacology and Pharmacodynamics. 2010;2:296-299.

Panda Siva Prasad, Haldar Pallab, Bera Samit, Kandar Chandi. Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats. Pharmaceutical biology. 2010;48:974-9. DOI: 10.3109/13880200903390051

Sukardiman Ervina M. The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine: A systematic review. Heliyon. 2020;6(3): e03536. DOI: 10.1016/j.heliyon.2020.e03536 Published 2020 Mar 10.

Harborne JB: Phytochemical Methods, A Guide to Modern Techniques of Plant Analysis. New Delhi, Springer (India) Pvt. Ltd; 1998.

Islam Zahirul, Tahsin Md, Faisal Ahmad, Tithi Tanzia, Tasnim Tasnova, Nila Tahmina, Gorapi Md, Nadvi Faisal, Mridula Tasneem, Choudhury Abu, Chowhdury Jakir Ahmed, Kabir Shaila, Amran Md. In vivo Assessment of antidiabetic potential and mapping of pharmacological properties of ethanolic extract of leaves of Coccinia grandis on Alloxan-induced Diabetic Rats. Asian Journal of Advanced Research and Reports. 2019;1-9. DOI: 10.9734/ajarr/2019/v7i230169